HMM Summary Page: TIGR02154

Functionphosphate regulon transcriptional regulatory protein PhoB
Gene SymbolphoB
Trusted Cutoff296.20
Domain Trusted Cutoff296.20
Noise Cutoff260.85
Domain Noise Cutoff260.85
Isology Typeequivalog
HMM Length226
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0000156: two-component response regulator activity molecular_function
GO:0000160: two-component signal transduction system (phosphorelay) biological_process
GO:0003700: sequence-specific DNA binding transcription factor activity molecular_function
GO:0006355: regulation of transcription, DNA-dependent biological_process
GO:0006796: phosphate-containing compound metabolic process biological_process
AuthorSelengut J
Entry DateApr 2 2004 11:38AM
Last ModifiedFeb 14 2011 3:27PM
CommentPhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself [1]. It is often found proximal to genes for the high-affinity phosphate ABC transporter (pstSCAB; GenProp0190) and presumably regulates these as well.
ReferencesRN [1] RM PMID: 3537313 RT Nucleotide sequence of the phoB gene, the positive regulatory gene for the phosphate regulon of Escherichia coli K-12. RA Makino K, Shinagawa H, Amemura M, Nakata A. RL J Mol Biol. 1986 Jul 5;190(1):37-44.
Genome PropertyGenProp0190: phosphate ABC transporter (pstSCAB-phoU) (HMM)