HMM Summary Page: TIGR02146

Functionhomocitrate synthase
Gene SymbollysS
Trusted Cutoff413.55
Domain Trusted Cutoff413.55
Noise Cutoff400.45
Domain Noise Cutoff400.45
Isology Typehypoth_equivalog
EC Number2.3.3.14
HMM Length344
AuthorSelengut J
Entry DateMar 11 2004 4:33PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model includes the yeast LYS21 gene which carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. A related pathway is found in Thermus thermophilus [1]. This enzyme is closely related to 2-isopropylmalate synthase (LeuA) and citramalate synthase (CimA), both of which are present in the euryarchaeota. Some archaea have a separate homocitrate synthase (AksA) which also synthesizes longer homocitrate analogs [2].
ReferencesRN [1] RM PMID: 10613839 RT A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis RA Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H RL Genome Res. 1999 Dec;9(12):1175-83 RN [2] RM PMID: 9665716 RT Alpha-keto acid chain elongation reactions involved in the biosynthesis of coenzyme B (7-mercaptoheptanoyl threonine phosphate) in methanogenic Archaea. RA Howell DM, Harich K, Xu H, White RH. RL Biochemistry. 1998 Jul 14;37(28):10108-17. DR HAMAP; MF_01025; 4 of 96
Genome PropertyGenProp0193: lysine biosynthesis via alpha-aminoadipate (AAA pathway) (HMM)