| Accession | TIGR02129 |
| Name | hisA_euk |
| Function | phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase |
| Gene Symbol | hisA |
| Trusted Cutoff | 229.30 |
| Domain Trusted Cutoff | 229.30 |
| Noise Cutoff | 149.80 |
| Domain Noise Cutoff | 149.80 |
| Isology Type | equivalog |
| EC Number | 5.3.1.16 |
| HMM Length | 255 |
| Mainrole Category | Amino acid biosynthesis |
| Subrole Category | Histidine family |
| Gene Ontology Term | GO:0000105: histidine biosynthetic process biological_process |
| | GO:0003949: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity molecular_function |
| Author | Selengut J |
| Entry Date | Feb 25 2004 11:54AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This enzyme acts in the biosynthesis of histidine and has been characterized in S. cerevisiae [1] and Arabidopsis [2] where it complements the E. coli HisA gene. In eukaryotes the gene is known as HIS6. In bacteria, this gene is found in Fibrobacter succinogenes, presumably due to lateral gene transfer from plants in the rumen gut. |
| References | RN [1]
RM PMID: 9332345
RT Paralogous histidine biosynthetic genes: evolutionary analysis of the Saccharomyces cerevisiae HIS6 and HIS7 genes
RA Fani R, Tamburini E, Mori E, Lazcano A, Lio P, Barberio C, Casalone E, Cavalieri D, Perito B, Polsinelli M
RL Gene. 1997 Sep 15;197(1-2):9-17
RN [2]
RM PMID: 9747713
RT Molecular cloning and characterization of the gene encoding N'-[(5'-phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (BBM II) isomerase from Arabidopsis thaliana
RA Fujimori K, Tada S, Kanai S, Ohta D
RL Mol Gen Genet. 1998 Aug;259(2):216-23 |
| Genome Property | GenProp0109: histidine biosynthesis from ribose-5-phosphate (HMM) |
