HMM Summary Page: TIGR02129

Functionphosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene SymbolhisA
Trusted Cutoff229.30
Domain Trusted Cutoff229.30
Noise Cutoff149.80
Domain Noise Cutoff149.80
Isology Typeequivalog
EC Number5.3.1.16
HMM Length255
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryHistidine family
Gene Ontology TermGO:0000105: histidine biosynthetic process biological_process
GO:0003949: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity molecular_function
AuthorSelengut J
Entry DateFeb 25 2004 11:54AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme acts in the biosynthesis of histidine and has been characterized in S. cerevisiae [1] and Arabidopsis [2] where it complements the E. coli HisA gene. In eukaryotes the gene is known as HIS6. In bacteria, this gene is found in Fibrobacter succinogenes, presumably due to lateral gene transfer from plants in the rumen gut.
ReferencesRN [1] RM PMID: 9332345 RT Paralogous histidine biosynthetic genes: evolutionary analysis of the Saccharomyces cerevisiae HIS6 and HIS7 genes RA Fani R, Tamburini E, Mori E, Lazcano A, Lio P, Barberio C, Casalone E, Cavalieri D, Perito B, Polsinelli M RL Gene. 1997 Sep 15;197(1-2):9-17 RN [2] RM PMID: 9747713 RT Molecular cloning and characterization of the gene encoding N'-[(5'-phosphoribosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide (BBM II) isomerase from Arabidopsis thaliana RA Fujimori K, Tada S, Kanai S, Ohta D RL Mol Gen Genet. 1998 Aug;259(2):216-23
Genome PropertyGenProp0109: histidine biosynthesis from ribose-5-phosphate (HMM)