HMM Summary Page: TIGR02119

Functionsodium/pantothenate symporter
Gene SymbolpanF
Trusted Cutoff328.05
Domain Trusted Cutoff328.05
Noise Cutoff323.05
Domain Noise Cutoff323.05
Isology Typeequivalog
HMM Length471
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPantothenate and coenzyme A
Gene Ontology TermGO:0015498: pantothenate:sodium symporter activity molecular_function
GO:0015887: pantothenate transmembrane transport biological_process
GO:0015937: coenzyme A biosynthetic process biological_process
AuthorHaft DH
Entry DateFeb 9 2004 9:42AM
Last ModifiedFeb 14 2011 3:27PM
CommentPantothenate (vitamin B5) is a precursor of coenzyme A and is made from aspartate and 2-oxoisovalerate in most bacteria with completed genome sequences. However, some pathogens must import pantothenate. This HMM describes PanF, a sodium/pantothenate symporter, from a larger family of Sodium/substrate symporters (PF00474). Several species that have this transporter appear to lack all enzymes of pantothenate biosynthesis, namely Haemophilus influenzae, Pasteurella multocida, Fusobacterium nucleatum, and Borrelia burgdorferi.
ReferencesDR PFAM; PF00474; Sodium/substrate symporters DR SWISSPROT; P16256; Escherichia coli RM 2193919 RT Cloning, sequence, and expression of the pantothenate permease (panF) gene of Escherichia coli. RA Jackowski S, Alix JH. RL J Bacteriol. 1990 Jul;172(7):3842-8.
Genome PropertyGenProp0171: coenzyme A biosynthesis from pantothenate (HMM)