| Accession | TIGR02119 |
| Name | panF |
| Function | sodium/pantothenate symporter |
| Gene Symbol | panF |
| Trusted Cutoff | 328.05 |
| Domain Trusted Cutoff | 328.05 |
| Noise Cutoff | 323.05 |
| Domain Noise Cutoff | 323.05 |
| Isology Type | equivalog |
| HMM Length | 471 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Pantothenate and coenzyme A |
| Gene Ontology Term | GO:0015498: pantothenate:sodium symporter activity molecular_function |
| | GO:0015887: pantothenate transmembrane transport biological_process |
| | GO:0015937: coenzyme A biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Feb 9 2004 9:42AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Pantothenate (vitamin B5) is a precursor of coenzyme A and is made from aspartate and 2-oxoisovalerate in most bacteria with completed genome sequences. However, some pathogens must import pantothenate. This HMM describes PanF, a sodium/pantothenate symporter, from a larger family of Sodium/substrate symporters (PF00474). Several species that have this transporter appear to lack all enzymes of pantothenate biosynthesis, namely Haemophilus influenzae, Pasteurella multocida, Fusobacterium nucleatum, and Borrelia burgdorferi. |
| References | DR PFAM; PF00474; Sodium/substrate symporters
DR SWISSPROT; P16256; Escherichia coli
RM 2193919
RT Cloning, sequence, and expression of the pantothenate permease (panF) gene of Escherichia coli.
RA Jackowski S, Alix JH.
RL J Bacteriol. 1990 Jul;172(7):3842-8. |
| Genome Property | GenProp0171: coenzyme A biosynthesis from pantothenate (HMM) |
