| Accession | TIGR02113 |
| Name | coaC_strep |
| Function | phosphopantothenoylcysteine decarboxylase |
| Gene Symbol | coaC |
| Trusted Cutoff | 261.40 |
| Domain Trusted Cutoff | 261.40 |
| Noise Cutoff | 213.20 |
| Domain Noise Cutoff | 213.20 |
| Isology Type | equivalog |
| EC Number | 4.1.1.36 |
| HMM Length | 177 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Pantothenate and coenzyme A |
| Gene Ontology Term | GO:0004633: phosphopantothenoylcysteine decarboxylase activity molecular_function |
| | GO:0015937: coenzyme A biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Jan 27 2004 9:03AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | In most bacteria, a single bifunctional protein catalyses phosphopantothenoylcysteine decarboxylase and phosphopantothenate--cysteine ligase activities, sequential steps in coenzyme A biosynthesis (see TIGR00521). These activities reside in separate proteins encoded by tandem genes in some bacterial lineages. This model describes proteins from the genera Streptococcus and Enterococcus homologous to the N-terminal region of TIGR00521, corresponding to phosphopantothenoylcysteine decarboxylase activity. |
| References | RM 11278255
RT Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria.
RA Strauss E, Kinsland C, Ge Y, McLafferty FW, Begley TP.
RL J Biol Chem. 2001 Apr 27; 276(17): 13513-6. |
| Genome Property | GenProp0171: coenzyme A biosynthesis from pantothenate (HMM) |
