HMM Summary Page: TIGR02108

Functioncoenzyme PQQ biosynthesis protein B
Gene SymbolpqqB
Trusted Cutoff303.55
Domain Trusted Cutoff303.55
Noise Cutoff76.85
Domain Noise Cutoff76.85
Isology Typeequivalog
HMM Length302
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0018189: pyrroloquinoline quinone biosynthetic process biological_process
AuthorHaft DH
Entry DateJan 22 2004 1:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes coenzyme PQQ biosynthesis protein B, a gene required for the biosynthesis of pyrrolo-quinoline-quinone (coenzyme PQQ). PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. Note that this gene appears to be required for PQQ in biosynthesis in Methylobacterium extorquens (under the name pqqG) and in Klebiella pneumoniae but that the equivalent pqqV in Acinetobacter calcoaceticus is not necessary for heterologous expression of PQQ biosynthesis in E. coli. Based on this latter finding, it is suggested (Goosen, et al. 1989) that PqqB might be a transporter or a PQQ-dependent enzyme rather than a PQQ biosynthesis enzyme.
ReferencesRM 2536663 RT Acinetobacter calcoaceticus genes involved in biosynthesis of the coenzyme pyrrolo-quinoline-quinone: nucleotide sequence and expression in Escherichia coli K-12. RA Goosen N, Horsman HP, Huinen RG, van de Putte P. RL J Bacteriol. 1989 Jan; 171(1): 447-55. DR HAMAP; MF_00653; 39 of 39
Genome PropertyGenProp0170: coenzyme PQQ biosynthesis (HMM)