HMM Summary Page: TIGR02101

Functiontype III secretion target, IpaC/SipC family
Trusted Cutoff130.75
Domain Trusted Cutoff130.75
Noise Cutoff95.10
Domain Noise Cutoff95.10
Isology Typesubfamily
HMM Length314
Mainrole CategoryCellular processes
Subrole CategoryPathogenesis
AuthorHaft DH
Entry DateJan 17 2004 11:37AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a family of proteins associated with bacterial type III secretion systems, which are injection machines for virulence factors into host cell cytoplasm. Characterized members of this protein family are known to be secreted and are described as invasins, including IpaC from Shigella flexneri (SP:P18012) and SipC from Salmonella typhimurium (GB:AAA75170.1). Members may be referred to as invasins, pathogenicity island effectors, and cell invasion proteins.
ReferencesRM 7608068 RT Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells. RA Kaniga K, Tucker S, Trollinger D, Galan JE. RL J Bacteriol. 1995 Jul; 177(14): 3965-71.
Genome PropertyGenProp0052: type III secretion (HMM)