HMM Summary Page: TIGR02086

Function3-isopropylmalate dehydratase, large subunit
Trusted Cutoff410.15
Domain Trusted Cutoff410.15
Noise Cutoff399.05
Domain Noise Cutoff399.05
Isology Typesubfamily
HMM Length411
AuthorSelengut J
Entry DateDec 30 2003 12:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis subfamily is a subset of the larger HacA family (Homoaconitate hydratase family, TIGR01343) and is most closely related to the 3-isopropylmalate dehydratase, large subunits which form TIGR00170. This subfamily includes the members of TIGR01343 which are gene clustered with other genes of leucine biosynthesis. The rest of the subfamily includes mainly archaeal species which exhibit two hits to this model. In these cases it is possible that one or the other of the hits does not have a 3-isopropylmalate dehydratase activity but rather one of the other related aconitase-like activities.
References DR HAMAP; MF_01027; 60 of 61
Genome PropertyGenProp0164: leucine biosynthesis from pyruvate and acetyl-CoA (HMM)