HMM Summary Page: TIGR02083

Function3-isopropylmalate dehydratase, large subunit
Gene SymbolleuC
Trusted Cutoff610.65
Domain Trusted Cutoff610.65
Noise Cutoff578.95
Domain Noise Cutoff578.95
Isology Typeequivalog
EC Number4.2.1.33
HMM Length419
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryPyruvate family
Gene Ontology TermGO:0003861: 3-isopropylmalate dehydratase activity molecular_function
GO:0009098: leucine biosynthetic process biological_process
GO:0009316: 3-isopropylmalate dehydratase complex cellular_component
AuthorSelengut J
Entry DateDec 23 2003 12:13PM
Last ModifiedFeb 14 2011 3:27PM
CommentHomoaconitase, aconitase, and 3-isopropylmalate dehydratase have similar overall structures. All are dehydratases (EC 4.2.1.-) and bind a Fe-4S iron-sulfur cluster. 3-isopropylmalate dehydratase is split into large (leuC) and small (leuD) chains in eubacteria. Several pairs of archaeal proteins resemble the leuC and leuD pair in length and sequence but even more closely resemble the respective domains of homoaconitase, and their identity is uncertain. These homologs are described by a separate model of subfamily (rather than equivalog) homology type (TIGR01343). This model along with TIGR00170 describe clades which consist only of LeuC sequences. Here, the genes from Pyrococcus furiosus, Clostridium acetobutylicum, Thermotoga maritima and others are gene clustered with related genes from the leucine biosynthesis pathway.
References DR HAMAP; MF_01027; 27 of 61
Genome PropertyGenProp0164: leucine biosynthesis from pyruvate and acetyl-CoA (HMM)
GenProp0193: lysine biosynthesis via alpha-aminoadipate (AAA pathway) (HMM)