HMM Summary Page: TIGR02082

Functionmethionine synthase
Gene SymbolmetH
Trusted Cutoff1010.85
Domain Trusted Cutoff1010.85
Noise Cutoff486.10
Domain Noise Cutoff486.10
Isology Typeequivalog
EC Number2.1.1.13
HMM Length1182
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAspartate family
Gene Ontology TermGO:0008705: methionine synthase activity molecular_function
GO:0009086: methionine biosynthetic process biological_process
AuthorHaft DH
Entry DateDec 23 2003 11:23AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family represents 5-methyltetrahydrofolate--homocysteine methyltransferase (EC, one of at least three different enzymes able to convert homocysteine to methionine by transferring a methyl group on to the sulfur atom. It is also called the vitamin B12(or cobalamine)-dependent methionine synthase. Other methionine synthases include 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (MetE, EC, the cobalamin-independent methionine synthase) and betaine-homocysteine methyltransferase.
ReferencesDR EXPERIMENTAL; SP|P13009; Escherichia coli DR EXPERIMENTAL; SP|Q99707; Homo sapiens
Genome PropertyGenProp0161: methionine biosynthesis from homoserine (HMM)
GenProp0284: cobalamin-utilizing enzymes (HMM)