HMM Summary Page: TIGR02077

Functionthr operon leader peptide
Gene SymbolthrL
Trusted Cutoff22.95
Domain Trusted Cutoff22.95
Noise Cutoff20.95
Domain Noise Cutoff20.95
Isology Typeequivalog
HMM Length23
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAspartate family
Gene Ontology TermGO:0031554: regulation of transcription termination, DNA-dependent biological_process
GO:0031556: transcriptional attenuation by ribosome biological_process
AuthorHaft DH
Entry DateDec 15 2003 12:58PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of examples of the threonine biosynthesis (thr) operon leader peptide, also called the thr operon attenuator. The small gene for this peptide is often missed in genome annotation. It should be looked for in genomes of the proteobacteria, immediately upstream of genes for threonine biosynthesis, typically aspartokinase I/homoserine dehydrogenase, homoserine kinase, and threonine synthase. Transcription of the rest of the Thr operon is attenuated (mostly turned off) unless the ribosome pauses during a stretch of the leader sequence rich in both Ile (made from Thr) and in Thr itself because of the scarcity of those amino acids at the time. The leader peptide itself, once made, may have no role other than to be degraded. Similar systems exist for some other amino acid biosynthetic operons, such as Trp.
References DR HAMAP; MF_01907; 23 of 23