HMM Summary Page: TIGR02076

Functionputative uridylate kinase
Gene SymbolpyrH
Trusted Cutoff158.05
Domain Trusted Cutoff158.05
Noise Cutoff114.50
Domain Noise Cutoff114.50
Isology Typehypoth_equivalog
EC Number2.7.4.-
HMM Length222
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryNucleotide and nucleoside interconversions
AuthorHaft DH
Entry DateDec 12 2003 1:38PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of the archaeal and spirochete proteins most closely related to bacterial uridylate kinases (TIGR02075), an enzyme involved in pyrimidine biosynthesis. Members are likely, but not known, to be functionally equivalent to their bacterial counterparts. However, substantial sequence differences suggest that regulatory mechanisms may be different; the bacterial form is allosterically regulated by GTP.
References DR HAMAP; MF_01220; 46 of 538