HMM Summary Page: TIGR02075

FunctionUMP kinase
Gene SymbolpyrH
Trusted Cutoff243.90
Domain Trusted Cutoff243.90
Noise Cutoff124.70
Domain Noise Cutoff124.70
Isology Typeequivalog
EC Number2.7.4.22
HMM Length233
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryNucleotide and nucleoside interconversions
Gene Ontology TermGO:0015949: nucleobase-containing small molecule interconversion biological_process
GO:0033862: UMP kinase activity molecular_function
AuthorHaft DH
Entry DateDec 12 2003 12:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein, also called UMP kinase, converts UMP to UDP by adding a phosphate from ATP. It is the first step in pyrimidine biosynthesis. GTP is an allosteric activator. In a large fraction of all bacterial genomes, the gene tends to be located immediately downstream of elongation factor Ts and upstream of ribosome recycling factor. A related protein family, believed to be equivalent in function and found in the archaea and in spirochetes, is described by a separate model, TIGR02076.
References DR HAMAP; MF_01220; 492 of 538