| Accession | TIGR02072 |
| Name | BioC |
| Function | malonyl-acyl carrier protein O-methyltransferase BioC |
| Gene Symbol | bioC |
| Trusted Cutoff | 184.95 |
| Domain Trusted Cutoff | 184.95 |
| Noise Cutoff | 134.85 |
| Domain Noise Cutoff | 134.85 |
| Isology Type | equivalog |
| EC Number | 2.1.1.- |
| HMM Length | 244 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Biotin |
| Gene Ontology Term | GO:0009102: biotin biosynthetic process biological_process |
| Author | Selengut J, Haft DH |
| Entry Date | Dec 10 2003 4:27PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. |
| References | RN [1]
RM PMID:22965231
RT The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis.
RA Lin S, Cronan JE
RL J Biol Chem. 2012 Oct 26;287(44):37010-20. |
| Genome Property | GenProp0036: biotin biosynthesis (HMM) |
