| Accession | TIGR02068 |
| Name | cya_phycin_syn |
| Function | cyanophycin synthetase |
| Gene Symbol | cphA |
| Trusted Cutoff | 730.70 |
| Domain Trusted Cutoff | 730.70 |
| Noise Cutoff | 319.25 |
| Domain Noise Cutoff | 319.25 |
| Isology Type | equivalog |
| EC Number | 6.3.2.29 6.3.2.30 |
| HMM Length | 864 |
| Mainrole Category | Cellular processes |
| Subrole Category | Biosynthesis of natural products |
| Gene Ontology Term | GO:0016874: ligase activity molecular_function |
| | GO:0051235: maintenance of location biological_process |
| Author | Haft DH |
| Entry Date | Dec 2 2003 1:03PM |
| Last Modified | Dec 19 2011 1:06PM |
| Comment | Cyanophycin is an insoluble storage polymer for carbon, nitrogen, and energy, found in most Cyanobacteria. The polymer has a backbone of L-aspartic acid, with most Asp side chain carboxyl groups attached to L-arginine. The polymer is made by this enzyme, cyanophycin synthetase, and degraded by cyanophycinase. Heterologously expressed cyanophycin synthetase in E. coli produces a closely related, water-soluble polymer with some Arg replaced by Lys. It is unclear whether enzymes that produce soluble cyanophycin-like polymers in vivo in non-Cyanobacterial species should be designated as cyanophycin synthetase itself or as a related enzyme. This model makes the designation as cyanophycin synthetase.
Cyanophycin synthesis is analogous to polyhydroxyalkanoic acid (PHA) biosynthesis, except that PHA polymers lack nitrogen and may be made under nitrogen-limiting conditions. |
| References | RM 11976746
RT Evaluation of non-cyanobacterial genome sequences for occurrence of genes encoding proteins homologous to cyanophycin synthetase and cloning of an active cyanophycin synthetase from Acinetobacter sp. strain DSM 587.
RA Krehenbrink M, Oppermann-Sanio FB, Steinbuchel A.
RL Arch Microbiol. 2002 May;177(5):371-80. Epub 2002 Feb 14. |
| Genome Property | GenProp0156: cyanophycin-like storage polymers (HMM) |
