| Accession | TIGR02064 |
| Name | dsrA |
| Function | sulfite reductase, dissimilatory-type alpha subunit |
| Gene Symbol | dsrA |
| Trusted Cutoff | 392.85 |
| Domain Trusted Cutoff | 392.85 |
| Noise Cutoff | 222.85 |
| Domain Noise Cutoff | 222.85 |
| Isology Type | equivalog |
| EC Number | 1.8.99.3 |
| HMM Length | 402 |
| Mainrole Category | Central intermediary metabolism |
| Subrole Category | Sulfur metabolism |
| Gene Ontology Term | GO:0018551: hydrogensulfite reductase activity molecular_function |
| | GO:0019420: dissimilatory sulfate reduction biological_process |
| Author | Brinkac L |
| Entry Date | Nov 25 2003 2:38PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Dissimilatory sulfite reductase catalyzes the six-electron reduction of sulfite to sulfide, as the terminal reaction in dissimilatory sulfate reduction. It remains unclear however, whether trithionate and thiosulfate serve as intermediate compounds to sulfide, or as end products of sulfite reduction [1].
Sulfite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulfur cluster prosthetic center [2]. Found in sulfate-reducing bacteria, these genes are commonly located in an unidirectional gene cluster [3].
This model describes the alpha subunit of sulfite reductase. |
| References | RN [1]
RM PMID: 7747930
RT Metabolism of sulfate-reducing prokaryotes.
RA Hansen TA
RL Antonie Van Leeuwenhoek. 1994;66(1-3):165-85. Review.
RN [2]
RM PMID: 1555572
RT The third subunit of desulfoviridin-type dissimilatory sulfite reductases.
RA Pierik AJ, Duyvis MG, van Helvoort JM, Wolbert RB, Hagen WR.
RL Eur J Biochem. 1992 Apr 1;205(1):111-5.
RN [3]
RM PMID: 11557144
RT A novel organization of the dissimilatory sulfite reductase operon of Thermodesulforhabdus norvegica verified by RT-PCR.
RA Larsen O, Lien T, Birkeland NK.
RL FEMS Microbiol Lett. 2001 Sep 11;203(1):81-5.
DR PFAM; PF01077; Nitrite and sulphite reductase 4Fe-4S domain
DR EXPERIEMENTAL; SP|P45574; Desulfovibrio vulgaris; purified protein formed mainly trithionate besides thiosulfate and sulfide in sulfite reduction coupled to hydrogenase and methyl viologen
DR OUTGROUP; SP|Q59110; Archaeoglobus fulgidus; Sulfite reductase, dissimilatory-type beta subunit |
| Genome Property | GenProp0155: dissimilatory sulfate reduction (HMM) |
