HMM Summary Page: TIGR02063

Functionribonuclease R
Gene Symbolrnr
Trusted Cutoff597.85
Domain Trusted Cutoff597.85
Noise Cutoff424.20
Domain Noise Cutoff424.20
Isology Typeequivalog
EC Number3.1.-.-
HMM Length711
Mainrole CategoryTranscription
Subrole CategoryDegradation of RNA
Gene Ontology TermGO:0006401: RNA catabolic process biological_process
GO:0008997: ribonuclease R activity molecular_function
AuthorHaft DH
Entry DateNov 25 2003 12:12PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of an exoribonuclease, ribonuclease R, also called VacB. It is one of the eight exoribonucleases reported in E. coli and is broadly distributed throughout the bacteria. In E. coli, double mutants of this protein and polynucleotide phosphorylase are not viable. Scoring between trusted and noise cutoffs to the model are shorter, divergent forms from the Chlamydiae, and divergent forms from the Campylobacterales (including Helicobacter pylori) and Leptospira interrogans.
ReferencesRN [1] RM 9603904 RT The vacB gene required for virulence in Shigella flexneri and Escherichia coli encodes the exoribonuclease RNase R. RA Cheng ZF, Zuo Y, Li Z, Rudd KE, Deutscher MP. RL J Biol Chem. 1998 Jun 5;273(23):14077-80. RN [2] RM 11948193 RT Purification and characterization of the Escherichia coli exoribonuclease RNase R. Comparison with RNase II. RA Cheng ZF, Deutscher MP. RL J Biol Chem. 2002 Jun 14;277(24):21624-9. Epub 2002 Apr 10.