| Accession | TIGR02061 |
| Name | aprA |
| Function | adenylylsulfate reductase, alpha subunit |
| Gene Symbol | aprA |
| Trusted Cutoff | 641.75 |
| Domain Trusted Cutoff | 641.75 |
| Noise Cutoff | 326.00 |
| Domain Noise Cutoff | 326.00 |
| Isology Type | equivalog |
| EC Number | 1.8.99.2 |
| HMM Length | 616 |
| Mainrole Category | Central intermediary metabolism |
| Subrole Category | Sulfur metabolism |
| Gene Ontology Term | GO:0009973: adenylyl-sulfate reductase activity molecular_function |
| | GO:0019420: dissimilatory sulfate reduction biological_process |
| | GO:0019425: sulfur oxidation, using siroheme sulfite reductase biological_process |
| Author | Brinkac L |
| Entry Date | Nov 24 2003 3:29PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | During dissimilatory sulfate reduction or sulfur oxidation, adenylylsulfate (APS) reductase catalyzes reversibly the two-electron reduction of APS to sulfite and AMP [1]. Found in several bacterial lineages and in Archaeoglobales, APS reductase is a heterodimer composed of an alpha subunit containing a noncovalently bound FAD, and a beta subunit containing two [4Fe-4S] clusters [1]. Described by this model is the alpha subunit of APS reductase, sharing common evolutionary origin with fumarate reductase/succinate dehydrogenase flavoproteins. |
| References | RN [1]
RM 10802060
RT Adenylylsulfate reductases from archaea and bacteria are 1:1 alphabeta-heterodimeric iron-sulfur flavoenzymes--high similarity of molecular properties emphasizes their central role in sulfur metabolism.
RA Fritz G, Buchert T, Huber H, Stetter KO, Kroneck PM.
RL FEBS Lett. 2000 May 4;473(1):63-6.
DR PFAM; PF02910; Fumarate reductase/succinate dehydrogenase flavoprotein C-terminal domain
DR PFAM; PF00890; FAD binding domain
DR EXPERIMENTAL; GP|2576391; Allochromatium vinosum; insertional inactivation resulted in inability to synthesize APS from sulfite and AMP.
DR EXPERIMENTAL; GP|2648887; Archaeoglobus fulgidus; purified by chromatography, with APS reductase activity measured by spectroscopy.
DR OUTGROUP; GP|2649111; Archaeoglobus fulgidus DSM4304; fumarate reductase, flavoprotein subunit. |
| Genome Property | GenProp0155: dissimilatory sulfate reduction (HMM) |
