Accession | TIGR02051 |
Name | MerR |
Function | Hg(II)-responsive transcriptional regulator |
Gene Symbol | merR |
Trusted Cutoff | 150.85 |
Domain Trusted Cutoff | 150.85 |
Noise Cutoff | 123.70 |
Domain Noise Cutoff | 123.70 |
Isology Type | equivalog |
HMM Length | 124 |
Mainrole Category | Cellular processes |
Subrole Category | Detoxification |
Gene Ontology Term | GO:0016563: transcription activator activity molecular_function |
Author | Selengut J |
Entry Date | Nov 7 2003 9:44AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM represents the mercury (II) responsive transcriptional activator of the mer organomercurial resistance operon [1]. This protein is a member of the MerR family of transcriptional activators (PF00376) and contains a distinctive pattern of cysteine residues in its metal binding loop, Cys-X(8)-Cys-Pro, as well as a conserved and critical cysteine at the N-terminal end of the dimerization helix [2]. |
References | RN [1]
RM PMID: 2492496
RT Homologous metalloregulatory proteins from both gram-positive and gram-negative bacteria control transcription of mercury resistance operons.
RA Helmann JD, Wang Y, Mahler I, Walsh CT.
RL J Bacteriol. 1989 Jan;171(1):222-9.
RN [2]
RM PMID: 12958362
RT Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR.
RA Changela A, Chen K, Xue Y, Holschen J, Outten CE, O'Halloran TV, Mondragon A.
RL Science. 2003 Sep 5;301(5638):1383-7. |
Genome Property | GenProp0151: resistance to mercury (HMM) |