HMM Summary Page: TIGR02051

FunctionHg(II)-responsive transcriptional regulator
Gene SymbolmerR
Trusted Cutoff150.85
Domain Trusted Cutoff150.85
Noise Cutoff123.70
Domain Noise Cutoff123.70
Isology Typeequivalog
HMM Length124
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0016563: transcription activator activity molecular_function
AuthorSelengut J
Entry DateNov 7 2003 9:44AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the mercury (II) responsive transcriptional activator of the mer organomercurial resistance operon [1]. This protein is a member of the MerR family of transcriptional activators (PF00376) and contains a distinctive pattern of cysteine residues in its metal binding loop, Cys-X(8)-Cys-Pro, as well as a conserved and critical cysteine at the N-terminal end of the dimerization helix [2].
ReferencesRN [1] RM PMID: 2492496 RT Homologous metalloregulatory proteins from both gram-positive and gram-negative bacteria control transcription of mercury resistance operons. RA Helmann JD, Wang Y, Mahler I, Walsh CT. RL J Bacteriol. 1989 Jan;171(1):222-9. RN [2] RM PMID: 12958362 RT Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR. RA Changela A, Chen K, Xue Y, Holschen J, Outten CE, O'Halloran TV, Mondragon A. RL Science. 2003 Sep 5;301(5638):1383-7.
Genome PropertyGenProp0151: resistance to mercury (HMM)