HMM Summary Page: TIGR02049

Functionglutamate--cysteine ligase
Gene SymbolgshA
Trusted Cutoff293.90
Domain Trusted Cutoff293.90
Noise Cutoff206.50
Domain Noise Cutoff206.50
Isology Typeequivalog
EC Number6.3.2.2
HMM Length403
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryGlutathione and analogs
Gene Ontology TermGO:0004357: glutamate-cysteine ligase activity molecular_function
GO:0006750: glutathione biosynthetic process biological_process
AuthorHaft DH
Entry DateNov 6 2003 3:48PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of a rare family of glutamate--cysteine ligases, demonstrated first in Thiobacillus ferrooxidans and present in a few other Proteobacteria. It is the first of two enzymes for glutathione biosynthesis. It is also called gamma-glutamylcysteine synthetase.
ReferencesRM 8828222 RT The gene for gamma-glutamylcysteine synthetase from Thiobacillus ferrooxidans has low homology to its Escherichia coli equivalent and is linked to the gene for citrate synthase. RA Powles R, Deane S, Rawlings D. RL Microbiology. 1996 Sep;142 ( Pt 9):2543-8.
Genome PropertyGenProp0030: glutathione biosynthesis (HMM)