HMM Summary Page: TIGR02048

Functionputative glutamate--cysteine ligase
Gene SymbolgshA
Trusted Cutoff249.05
Domain Trusted Cutoff249.05
Noise Cutoff72.70
Domain Noise Cutoff72.70
Isology Typeequivalog
EC Number6.3.2.2
HMM Length376
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryGlutathione and analogs
Gene Ontology TermGO:0004357: glutamate-cysteine ligase activity molecular_function
GO:0006750: glutathione biosynthetic process biological_process
AuthorHaft DH
Entry DateNov 6 2003 3:38PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of proteins believed (see Copley SD, Dhillon JK, 2002) to be the glutamate--cysteine ligases of several cyanobacteria, which are known to make glutathione.
ReferencesRN [1] RM 12049666 RT Lateral gene transfer and parallel evolution in the history of glutathione biosynthesis genes. RA Copley SD, Dhillon JK. RL Genome Biol. 2002;3(5):research0025. Epub 2002 Apr 29.
Genome PropertyGenProp0030: glutathione biosynthesis (HMM)