HMM Summary Page: TIGR02047

FunctionCd(II)/Pb(II)-responsive transcriptional regulator
Gene SymbolcadR
Trusted Cutoff151.45
Domain Trusted Cutoff151.45
Noise Cutoff139.35
Domain Noise Cutoff139.35
Isology Typeequivalog
HMM Length127
AuthorSelengut J
Entry DateNov 6 2003 3:23PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the cadmium(II) and/or lead(II) responsive transcriptional activator of the proteobacterial metal efflux system [1,2]. This protein is a member of the MerR family of transcriptional activators (PF00376) and contains a distinctive pattern of cysteine residues in its metal binding loop, Cys-X(6-9)-Cys, as well as a conserved and critical cysteine at the N-terminal end of the dimerization helix [3].
ReferencesRN [1] RM PMID: 11282588 RT Chromosomal locus for cadmium resistance in Pseudomonas putida consisting of a cadmium-transporting ATPase and a MerR family response regulator. RA Lee SW, Glickmann E, Cooksey DA. RL Appl Environ Microbiol. 2001 Apr;67(4):1437-44. RN [2] RM PMID: 11544228 RT Cloning and functional analysis of the pbr lead resistance determinant of Ralstonia metallidurans CH34. RA Borremans B, Hobman JL, Provoost A, Brown NL, van Der Lelie D. RL J Bacteriol. 2001 Oct;183(19):5651-8. RN [3] RM PMID: 12958362 RT Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR. RA Changela A, Chen K, Xue Y, Holschen J, Outten CE, O'Halloran TV, Mondragon A. RL Science. 2003 Sep 5;301(5638):1383-7.