HMM Summary Page: TIGR02044

FunctionCu(I)-responsive transcriptional regulator
Gene SymbolcueR
Trusted Cutoff147.40
Domain Trusted Cutoff147.40
Noise Cutoff116.90
Domain Noise Cutoff116.90
Isology Typeequivalog
HMM Length127
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0003700: sequence-specific DNA binding transcription factor activity molecular_function
GO:0006355: regulation of transcription, DNA-dependent biological_process
GO:0006878: cellular copper ion homeostasis biological_process
GO:0046688: response to copper ion biological_process
AuthorSelengut J
Entry DateNov 3 2003 3:49PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the copper-, silver- and gold- (I) responsive transcriptional activator of the gamma proteobacterial copper efflux system [1]. This protein is a member of the MerR family of transcriptional activators (PF00376) and contains a distinctive pattern of cysteine residues in its metal binding loop, Cys-X7-Cys. This family also lacks a conserved cysteine at the N-terminal end of the dimerization helix which is required for the binding of divalent metals such as zinc; here it is replaced by a serine residue [2].
ReferencesRN [1] RM PMID: 11136469 RT CueR (YbbI) of Escherichia coli is a MerR family regulator controlling expression of the copper exporter CopA. RA Stoyanov JV, Hobman JL, Brown NL. RL Mol Microbiol. 2001 Jan;39(2):502-11. RN [2] RM PMID: 12958362 RT Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR. RA Changela A, Chen K, Xue Y, Holschen J, Outten CE, O'Halloran TV, Mondragon A. RL Science. 2003 Sep 5;301(5638):1383-7.