HMM Summary Page: TIGR02043
Accession | TIGR02043 |
Name | ZntR |
Function | Zn(II)-responsive transcriptional regulator |
Gene Symbol | zntR |
Trusted Cutoff | 167.95 |
Domain Trusted Cutoff | 167.95 |
Noise Cutoff | 121.70 |
Domain Noise Cutoff | 121.70 |
Isology Type | equivalog |
HMM Length | 131 |
Mainrole Category | Regulatory functions |
Subrole Category | DNA interactions |
Gene Ontology Term | GO:0006882: cellular zinc ion homeostasis biological_process |
GO:0010043: response to zinc ion biological_process | |
GO:0042156: zinc-mediated transcriptional activator activity molecular_function | |
Author | Selengut J |
Entry Date | Nov 3 2003 2:41PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM represents the zinc and cadmium (II) responsive transcriptional activator of the gamma proteobacterial zinc efflux system [1]. This protein is a member of the MerR family of transcriptional activators (PF00376) and contains a distinctive pattern of cysteine residues in its metal binding loop, Cys-Cys-X(8-9)-Cys, as well as a conserved and critical cysteine at the N-terminal end of the dimerization helix [1]. |
References | RN [1] RM PMID: 10048032 RT ZntR is a Zn(II)-responsive MerR-like transcriptional regulator of zntA in Escherichia coli. RA Brocklehurst KR, Hobman JL, Lawley B, Blank L, Marshall SJ, Brown NL, Morby AP. RL Mol Microbiol. 1999 Feb;31(3):893-902. RN [2] RM PMID: 12958362 RT Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR. RA Changela A, Chen K, Xue Y, Holschen J, Outten CE, O'Halloran TV, Mondragon A. RL Science. 2003 Sep 5;301(5638):1383-7. |