HMM Summary Page: TIGR02043

FunctionZn(II)-responsive transcriptional regulator
Gene SymbolzntR
Trusted Cutoff167.95
Domain Trusted Cutoff167.95
Noise Cutoff121.70
Domain Noise Cutoff121.70
Isology Typeequivalog
HMM Length131
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0006882: cellular zinc ion homeostasis biological_process
GO:0010043: response to zinc ion biological_process
GO:0042156: zinc-mediated transcriptional activator activity molecular_function
AuthorSelengut J
Entry DateNov 3 2003 2:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the zinc and cadmium (II) responsive transcriptional activator of the gamma proteobacterial zinc efflux system [1]. This protein is a member of the MerR family of transcriptional activators (PF00376) and contains a distinctive pattern of cysteine residues in its metal binding loop, Cys-Cys-X(8-9)-Cys, as well as a conserved and critical cysteine at the N-terminal end of the dimerization helix [1].
ReferencesRN [1] RM PMID: 10048032 RT ZntR is a Zn(II)-responsive MerR-like transcriptional regulator of zntA in Escherichia coli. RA Brocklehurst KR, Hobman JL, Lawley B, Blank L, Marshall SJ, Brown NL, Morby AP. RL Mol Microbiol. 1999 Feb;31(3):893-902. RN [2] RM PMID: 12958362 RT Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR. RA Changela A, Chen K, Xue Y, Holschen J, Outten CE, O'Halloran TV, Mondragon A. RL Science. 2003 Sep 5;301(5638):1383-7.