HMM Summary Page: TIGR02038

Functionperiplasmic serine peptidase DegS
Gene SymboldegS
Trusted Cutoff422.95
Domain Trusted Cutoff422.95
Noise Cutoff291.85
Domain Noise Cutoff291.85
Isology Typeequivalog
EC Number3.4.21.-
HMM Length351
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0008236: serine-type peptidase activity molecular_function
GO:0030288: outer membrane-bounded periplasmic space cellular_component
GO:0045152: antisigma factor binding molecular_function
AuthorHaft DH
Entry DateOct 24 2003 3:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of the periplasmic serine protease DegS (HhoB), a shorter paralog of protease DO (HtrA, DegP) and DegQ (HhoA). It is found in E. coli and several other Proteobacteria of the gamma subdivision. It contains a trypsin domain and a single copy of PDZ domain (in contrast to DegP with two copies). A critical role of this DegS is to sense stress in the periplasm and partially degrade an inhibitor of sigma(E).
ReferencesRN [1] RM 11442831 RT degS (hhoB) is an essential Escherichia coli gene whose indispensable function is to provide sigma (E) activity. RA Alba BM, Zhong HJ, Pelayo JC, Gross CA. RL Mol Microbiol. 2001 Jun;40(6):1323-33. RN [2] RM 12679025 RT A stress sensor for the bacterial periplasm. RA Young JC, Hartl FU. RL Cell. 2003 Apr 4;113(1):1-2.