| Accession | TIGR02037 |
| Name | degP_htrA_DO |
| Function | peptidase Do |
| Trusted Cutoff | 416.20 |
| Domain Trusted Cutoff | 416.20 |
| Noise Cutoff | 365.80 |
| Domain Noise Cutoff | 365.80 |
| Isology Type | subfamily |
| EC Number | 3.4.21.- |
| HMM Length | 434 |
| Mainrole Category | Protein fate |
| Subrole Category | Protein folding and stabilization |
| Gene Ontology Term | GO:0004252: serine-type endopeptidase activity molecular_function |
| | GO:0005515: protein binding molecular_function |
| | GO:0006508: proteolysis biological_process |
| | GO:0006950: response to stress biological_process |
| | GO:0030288: outer membrane-bounded periplasmic space cellular_component |
| Author | Haft DH |
| Entry Date | Oct 24 2003 10:12AM |
| Last Modified | Feb 25 2011 12:36PM |
| Comment | This family consists of a set proteins various designated DegP, heat shock protein HtrA, and protease DO. The ortholog in Pseudomonas aeruginosa is designated MucD and is found in an operon that controls mucoid phenotype. This family also includes the DegQ (HhoA) paralog in E. coli which can rescue a DegP mutant, but not the smaller DegS paralog, which cannot. Members of this family are located in the periplasm and have separable functions as both protease and chaperone. Members have a trypsin domain and two copies of a PDZ domain. This protein protects bacteria from thermal and other stresses and may be important for the survival of bacterial pathogens.// The chaperone function is dominant at low temperatures, whereas the proteolytic activity is turned on at elevated temperatures. [2] |
| References | DR PFAM; PF00089; trypsin
DR PFAM; PF00595; PDZ domain
RN [1]
RM PMID: 11919638
RT Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine.
RA Krojer T, Garrido-Franco M, Huber R, Ehrmann M, Clausen T.
RL Nature. 2002 Mar 28;416(6879):455-9.
RN [2]
RM PMID: 12458220
RT Crystal structure of the protease domain of a heat-shock protein HtrA from Thermotoga maritima.
AU Kim DY, Kim DR, Ha SC, Lokanath NK, Lee CJ, Hwang HY, Kim KK
RL J Biol Chem 2003 Feb 21;278(8):6543-51. Epub 2002 Nov 27. |
| Genome Property | GenProp0928: OMP chaperone system: SurA-Skp-DegP (HMM) |
