| Accession | TIGR02025 |
| Name | BchH |
| Function | magnesium chelatase, H subunit |
| Gene Symbol | bchH |
| Trusted Cutoff | 829.00 |
| Domain Trusted Cutoff | 829.00 |
| Noise Cutoff | 823.75 |
| Domain Noise Cutoff | 823.75 |
| Isology Type | equivalog |
| EC Number | 6.6.1.1 |
| HMM Length | 1271 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Chlorophyll and bacteriochlorphyll |
| Gene Ontology Term | GO:0005488: binding molecular_function |
| | GO:0010007: magnesium chelatase complex cellular_component |
| | GO:0015995: chlorophyll biosynthetic process biological_process |
| | GO:0016851: magnesium chelatase activity molecular_function |
| Author | Selengut J |
| Entry Date | Oct 16 2003 11:17AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents the H subunit of the magnesium chelatase complex responsible for magnesium insertion into the protoporphyrin IX ring in the biosynthesis of both chlorophyll and bacteriochlorophyll. In chlorophyll-utilizing species, this gene is known as ChlH, while in bacteriochlorophyll-utilizing spoecies it is called BchH. Subunit H is the largest (~140kDa) of the three subunits (the others being BchD/ChlD and BchI/ChlI), and is known to bind protoporphyrin IX. Subunit H is homologous to the CobN subunit of cobaltochelatase and by anology with that enzyme, subunit H is believed to also bind the magnesium ion which is inserted into the ring. In conjunction with the hydrolysis of ATP by subunits I and D, a conformation change is believed to happen in subunit H causing the magnesium ion insertion into the distorted protoporphyrin ring [1]. |
| References | RN [1]
RM PMID: 12828371
RT Biosynthesis of chlorophylls from protoporphyrin IX.
RA Willows RD.
RL Nat Prod Rep. 2003 Jun;20(3):327-41. |
| Genome Property | GenProp0144: chlorophyllide a biosynthesis from protoporphyrin IX (HMM) |
