| Accession | TIGR02022 |
| Name | hutF |
| Function | formiminoglutamate deiminase |
| Gene Symbol | hutF |
| Trusted Cutoff | 413.05 |
| Domain Trusted Cutoff | 413.05 |
| Noise Cutoff | 213.90 |
| Domain Noise Cutoff | 213.90 |
| Isology Type | equivalog |
| EC Number | 3.5.3.13 |
| HMM Length | 455 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Amino acids and amines |
| Gene Ontology Term | GO:0019557: histidine catabolic process to glutamate and formate biological_process |
| | GO:0050416: formimidoylglutamate deiminase activity molecular_function |
| Author | Haft DH |
| Entry Date | Oct 15 2003 2:57PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | In some species, histidine utilization goes via urocanate to glutamate in four step, the last being removal of formamide. This HMM describes an alternate fourth step, formiminoglutamate hydrolase, which leads to N-formyl-L-glutamate. This product may be acted on by formylglutamate amidohydrolase (TIGR02017) and bypass glutamate as a product during its degradation. Alternatively, removal of formate (by EC 3.5.1.68) would yield glutamate. |
| References | RM 2842309
RT Organization and multiple regulation of histidine utilization genes in Pseudomonas putida.
RA Hu L, Phillips AT.
RL J Bacteriol. 1988 Sep;170(9):4272-9. |
| Genome Property | GenProp0145: histidine degradation to glutamate (HMM) |
