HMM Summary Page: TIGR02017

FunctionN-formylglutamate deformylase
Gene SymbolhutG
Trusted Cutoff278.75
Domain Trusted Cutoff278.75
Noise Cutoff127.20
Domain Noise Cutoff127.20
Isology Typeequivalog
EC Number3.5.1.68
HMM Length263
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0019557: histidine catabolic process to glutamate and formate biological_process
GO:0050129: N-formylglutamate deformylase activity molecular_function
AuthorHaft DH
Entry DateOct 14 2003 4:33PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn some species, histidine is converted to via urocanate and then formimino-L-glutamate to glutamate in four steps, where the fourth step is conversion of N-formimino-L-glutamate to L-glutamate and formamide. In others, that pathway from formimino-L-glutamate may differ, with the next enzyme being formiminoglutamate hydrolase (HutF) yielding N-formyl-L-glutamate. This HMM represents the enzyme N-formylglutamate deformylase, also called N-formylglutamate amidohydrolase, which then produces glutamate.
ReferencesRM 2842309 RT Organization and multiple regulation of histidine utilization genes in Pseudomonas putida. RA Hu L, Phillips AT. RL J Bacteriol. 1988 Sep;170(9):4272-9.
Genome PropertyGenProp0145: histidine degradation to glutamate (HMM)