HMM Summary Page: TIGR02011

Functioniron-sulfur cluster assembly protein IscA
Gene SymboliscA
Trusted Cutoff150.60
Domain Trusted Cutoff150.60
Noise Cutoff133.30
Domain Noise Cutoff133.30
Isology Typeequivalog
HMM Length105
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0005506: iron ion binding molecular_function
GO:0016226: iron-sulfur cluster assembly biological_process
AuthorSelengut J
Entry DateOct 7 2003 9:35AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the IscA component of the ISC system for iron-sulfur cluster assembly. The ISC system consists of IscRASU, HscAB and an Isc-specific ferredoxin [1]. IscA previously was believed to act as a scaffold [3] and now is seen as an iron donor protein. This clade is limited to the proteobacteria.
ReferencesRN [1] RM PMID: 11432781 RT Genetic analysis of the isc operon in Escherichia coli involved in the biogenesis of cellular iron-sulfur proteins. RA Tokumoto U, Takahashi Y. RL J Biochem (Tokyo). 2001 Jul;130(1):63-71. RN [2] RM PMID: 16877383 RT Interplay of IscA and IscU in biogenesis of iron-sulfur clusters. RA Yang J, Bitoun JP, Ding H RL J Biol Chem. 2006 Sep 22;281(38):27956-63. RN [3] RM PMID: 11319236 RT Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin. RA Ollagnier-de-Choudens S, Mattioli T, Takahashi Y, Fontecave M. RL J Biol Chem. 2001 Jun 22;276(25):22604-7. Epub 2001 Apr 23. DR HAMAP; MF_01429; 29 of 30
Genome PropertyGenProp0138: iron-sulfur cluster assembly iscSUA-hscBA-fdx system (HMM)