| Accession | TIGR02011 |
| Name | IscA |
| Function | iron-sulfur cluster assembly protein IscA |
| Gene Symbol | iscA |
| Trusted Cutoff | 150.60 |
| Domain Trusted Cutoff | 150.60 |
| Noise Cutoff | 133.30 |
| Domain Noise Cutoff | 133.30 |
| Isology Type | equivalog |
| HMM Length | 105 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Other |
| Gene Ontology Term | GO:0005506: iron ion binding molecular_function |
| | GO:0016226: iron-sulfur cluster assembly biological_process |
| Author | Selengut J |
| Entry Date | Oct 7 2003 9:35AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents the IscA component of the ISC system for iron-sulfur cluster assembly. The ISC system consists of IscRASU, HscAB and an Isc-specific ferredoxin [1]. IscA previously was believed to act as a scaffold [3] and now is seen as an iron donor protein.
This clade is limited to the proteobacteria. |
| References | RN [1]
RM PMID: 11432781
RT Genetic analysis of the isc operon in Escherichia coli involved in the biogenesis of cellular iron-sulfur proteins.
RA Tokumoto U, Takahashi Y.
RL J Biochem (Tokyo). 2001 Jul;130(1):63-71.
RN [2]
RM PMID: 16877383
RT Interplay of IscA and IscU in biogenesis of iron-sulfur clusters.
RA Yang J, Bitoun JP, Ding H
RL J Biol Chem. 2006 Sep 22;281(38):27956-63.
RN [3]
RM PMID: 11319236
RT Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin.
RA Ollagnier-de-Choudens S, Mattioli T, Takahashi Y, Fontecave M.
RL J Biol Chem. 2001 Jun 22;276(25):22604-7. Epub 2001 Apr 23.
DR HAMAP; MF_01429; 29 of 30 |
| Genome Property | GenProp0138: iron-sulfur cluster assembly iscSUA-hscBA-fdx system (HMM) |
