HMM Summary Page: TIGR02000

FunctionFe-S cluster assembly protein NifU
Gene SymbolnifU
Trusted Cutoff273.30
Domain Trusted Cutoff273.30
Noise Cutoff167.90
Domain Noise Cutoff167.90
Isology Typeequivalog
HMM Length290
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0005198: structural molecule activity molecular_function
GO:0009399: nitrogen fixation biological_process
GO:0016226: iron-sulfur cluster assembly biological_process
AuthorHaft DH
Entry DateSep 29 2003 5:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThree different but partially homologous Fe-S cluster assembly systems have been described: Isc, Suf, and Nif. The latter is associated with donation of an Fe-S cluster to nitrogenase in a number of nitrogen-fixing species. NifU, described here, consists of an N-terminal domain (PF01592) and a C-terminal domain (PF01106). Homologs with an equivalent domain archictecture from Helicobacter and Campylobacter, however, are excluded from this model by a high trusted cutoff. The model, therefore, is specific for NifU involved in nitrogenase maturation. The related model TIGR01999 homologous to the N-terminus of this model describes IscU from the Isc system as in E. coli, Saccharomyces cerevisiae, and Homo sapiens.
Genome PropertyGenProp0742: iron-sulfur cluster assembly NIF system (HMM)