HMM Summary Page: TIGR01999

FunctionFeS cluster assembly scaffold IscU
Gene SymboliscU
Trusted Cutoff192.40
Domain Trusted Cutoff192.40
Noise Cutoff155.90
Domain Noise Cutoff155.90
Isology Typeequivalog_domain
HMM Length124
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0005198: structural molecule activity molecular_function
GO:0016226: iron-sulfur cluster assembly biological_process
AuthorHaft DH
Entry DateSep 29 2003 4:55PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents IscU, a homolog of the N-terminal region of NifU, an Fe-S cluster assembly protein found mostly in nitrogen-fixing bacteria. IscU is considered part of the IscSUA-hscAB-fdx system of Fe-S assembly, whereas NifU is found in nitrogenase-containing (nitrogen-fixing) species. A NifU-type protein is also found in Helicobacter and Campylobacter. IscU and NifU are considered scaffold proteins on which Fe-S clusters are assembled before transfer to apoproteins. This model excludes true NifU proteins as in Klebsiella pneumoniae and Anabaena sp. as well as archaeal homologs. It includes largely proteobacterial and eukaryotic forms.
Genome PropertyGenProp0138: iron-sulfur cluster assembly iscSUA-hscBA-fdx system (HMM)