| Accession | TIGR01999 |
| Name | iscU |
| Function | FeS cluster assembly scaffold IscU |
| Gene Symbol | iscU |
| Trusted Cutoff | 192.40 |
| Domain Trusted Cutoff | 192.40 |
| Noise Cutoff | 155.90 |
| Domain Noise Cutoff | 155.90 |
| Isology Type | equivalog_domain |
| HMM Length | 124 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Other |
| Gene Ontology Term | GO:0005198: structural molecule activity molecular_function |
| | GO:0016226: iron-sulfur cluster assembly biological_process |
| Author | Haft DH |
| Entry Date | Sep 29 2003 4:55PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents IscU, a homolog of the N-terminal region of NifU, an Fe-S cluster assembly protein found mostly in nitrogen-fixing bacteria. IscU is considered part of the IscSUA-hscAB-fdx system of Fe-S assembly, whereas NifU is found in nitrogenase-containing (nitrogen-fixing) species. A NifU-type protein is also found in Helicobacter and Campylobacter. IscU and NifU are considered scaffold proteins on which Fe-S clusters are assembled before transfer to apoproteins. This model excludes true NifU proteins as in Klebsiella pneumoniae and Anabaena sp. as well as archaeal homologs. It includes largely proteobacterial and eukaryotic forms. |
| Genome Property | GenProp0138: iron-sulfur cluster assembly iscSUA-hscBA-fdx system (HMM) |
