HMM Summary Page: TIGR01992

FunctionPTS system, trehalose-specific IIBC component
Gene SymboltreP
Trusted Cutoff591.95
Domain Trusted Cutoff591.95
Noise Cutoff555.25
Domain Noise Cutoff555.25
Isology Typeequivalog_domain
EC Number2.7.1.69
HMM Length463
AuthorSelengut J
Entry DateSep 25 2003 11:16AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the fused enzyme II B and C components of the trehalose-specific PTS sugar transporter system [1]. Trehalose is converted to trehalose-6-phosphate in the process of translocation into the cell. These transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr) [2]. The exceptions to this rule are Staphylococci and Streptococci which contain their own A domain as a C-terminal fusion. This family is closely related to the sucrose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively). In E. coli, B. subtilis and P. fluorescens the presence of this gene is associated with the presence of trehalase which degrades T6P to glucose and glucose-6-P. Trehalose may also be transported (in Salmonella) via the mannose PTS or galactose permease systems [3], or (in Sinorhizobium, Thermococcus and Sulfolobus, for instance) by ABC transporters [4,5,6].
ReferencesRN [1] RM PMID: 11553642 RT Trehalose-6-phosphate phosphorylase is part of a novel metabolic pathway for trehalose utilization in Lactococcus lactis. RA Andersson U, Levander F, Radstrom P. RL J Biol Chem. 2001 Nov 16;276(46):42707-13. Epub 2001 Sep 11. RN [2] RM PMID: 12949193 RT Glucose and trehalose PTS permeases of Spiroplasma citri probably share a single IIA domain, enabling the spiroplasma to adapt quickly to carbohydrate changes in its environment. RA Andre A, Maccheroni W, Doignon F, Garnier M, Renaudin J. RL Microbiology. 2003 Sep;149(Pt 9):2687-2696. RN [3] RM PMID: 3023298 RT Transport of trehalose in Salmonella typhimurium. RA Postma PW, Keizer HG, Koolwijk P. RL J Bacteriol. 1986 Dec;168(3):1107-11. RN [4] RM PMID: 12003938 RT Redundancy in periplasmic binding protein-dependent transport systems for trehalose, sucrose, and maltose in Sinorhizobium meliloti. RA Jensen JB, Peters NK, Bhuvaneswari TV. RL J Bacteriol. 2002 Jun;184(11):2978-86. RN [5] RM PMID: 12454482 RT Crystallization and preliminary X-ray analysis of the trehalose/maltose ABC transporter MalFGK2 from Thermococcus litoralis. RA Schiefner A, Diederichs K, Hashimoto K, Boos W, Welte W. RL Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):2147-9. RN [6] RM PMID: 11260467 RT Sugar transport in Sulfolobus solfataricus is mediated by two families of binding protein-dependent ABC transporters. RA Elferink MG, Albers SV, Konings WN, Driessen AJ. RL Mol Microbiol. 2001 Mar;39(6):1494-503.
Genome PropertyGenProp0119: PTS transport system (HMM)
GenProp0119: PTS transport system (HMM)
GenProp0271: trehalose utilization (HMM)