HMM Summary Page: TIGR01983

Function3-demethylubiquinone-9 3-O-methyltransferase
Gene SymbolubiG
Trusted Cutoff102.95
Domain Trusted Cutoff102.95
Noise Cutoff77.30
Domain Noise Cutoff77.30
Isology Typeequivalog
EC Number2.1.1.64
HMM Length228
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMenaquinone and ubiquinone
Gene Ontology TermGO:0006744: ubiquinone biosynthetic process biological_process
GO:0008689: 3-demethylubiquinone-9 3-O-methyltransferase activity molecular_function
AuthorSelengut J
Entry DateSep 12 2003 9:31AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3) [1,2]. A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase.
ReferencesRN [1] RM PMID: 11583838 RT Ubiquinone biosynthesis in microorganisms. RA Meganathan R. RL FEMS Microbiol Lett. 2001 Sep 25;203(2):131-9. RN [2] RM PMID: 10419476 RT Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis. RA Poon WW, Barkovich RJ, Hsu AY, Frankel A, Lee PT, Shepherd JN, Myles DC, Clarke CF. RL J Biol Chem. 1999 Jul 30;274(31):21665-72. DR HAMAP; MF_00472; 168 of 172
Genome PropertyGenProp0136: ubiquinone biosynthesis from chorismate, aerobic (HMM)