HMM Summary Page: TIGR01982

Function2-polyprenylphenol 6-hydroxylase
Gene SymbolubiB
Trusted Cutoff487.55
Domain Trusted Cutoff487.55
Noise Cutoff465.35
Domain Noise Cutoff465.35
Isology Typeequivalog
EC Number1.14.13.-
HMM Length436
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMenaquinone and ubiquinone
Gene Ontology TermGO:0006744: ubiquinone biosynthetic process biological_process
GO:0016709: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen molecular_function
AuthorSelengut J
Entry DateSep 11 2003 5:05PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the enzyme (UbiB) which catalyzes the first hydroxylation step in the ubiquinone biosynthetic pathway in bacteria [1,2]. It is believed that the reaction is 2-polyprenylphenol -> 6-hydroxy-2-polyprenylphenol. This model finds hits primarily in the proteobacteria. The gene is also known as AarF in certain species.
ReferencesRN [1] RM PMID: 11583838 RT Ubiquinone biosynthesis in microorganisms. RA Meganathan R. RL FEMS Microbiol Lett. 2001 Sep 25;203(2):131-9. RN [2] RM PMID: 10960098 RT Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis. RA Poon WW, Davis DE, Ha HT, Jonassen T, Rather PN, Clarke CF. RL J Bacteriol. 2000 Sep;182(18):5139-46. DR HAMAP; MF_00414; 87 of 89
Genome PropertyGenProp0136: ubiquinone biosynthesis from chorismate, aerobic (HMM)