HMM Summary Page: TIGR01976

Functioncysteine desulfurase family protein
Trusted Cutoff352.35
Domain Trusted Cutoff352.35
Noise Cutoff283.70
Domain Noise Cutoff283.70
Isology Typehypoth_equivalog
HMM Length401
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
AuthorHaft DH
Entry DateSep 8 2003 5:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a subfamily of probable pyridoxal phosphate-dependent enzymes in the aminotransferase class V family (PF00266). The most closely related characterized proteins are active as cysteine desulfurases, selenocysteine lyases, or both; some are involved in FeS cofactor biosynthesis and are designated NifS. An active site Cys residue present in those sequences, in motifs resembling GHHC or GSAC, is not found in this family. The function of members of this family is unknown, but seems unlike to be as an aminotransferase.