HMM Summary Page: TIGR01967

FunctionRNA helicase HrpA
Gene SymbolhrpA
Trusted Cutoff722.75
Domain Trusted Cutoff722.75
Noise Cutoff558.45
Domain Noise Cutoff558.45
Isology Typeequivalog
EC Number3.6.4.13
HMM Length1284
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0006139: nucleobase-containing compound metabolic process biological_process
GO:0008026: ATP-dependent helicase activity molecular_function
AuthorHaft DH
Entry DateAug 29 2003 3:54PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB.
ReferencesRN [1] RM PMID:15186427 RT HrpA, a DEAH-box RNA helicase, is involved in mRNA processing of a fimbrial operon in Escherichia coli. RA Koo JT, Choe J, Moseley SL RL Mol Microbiol. 2004 Jun;52(6):1813-26. RN [2] RM PMID:24367266 RT HrpA, an RNA Helicase Involved in RNA Processing, Is Required for Mouse Infectivity and Tick Transmission of the Lyme Disease Spirochete. RA Salman-Dilgimen A, Hardy PO, Radolf JD, Caimano MJ, Chaconas G RL PLoS Pathog. 2013 Dec;9(12):e1003841.