HMM Summary Page: TIGR01966

Functionribonuclease PH
Gene Symbolrph
Trusted Cutoff141.50
Domain Trusted Cutoff141.50
Noise Cutoff117.35
Domain Noise Cutoff117.35
Isology Typeequivalog
EC Number2.7.7.56
HMM Length236
Mainrole CategoryTranscription
Subrole CategoryRNA processing
Gene Ontology TermGO:0004549: tRNA-specific ribonuclease activity molecular_function
GO:0008033: tRNA processing biological_process
AuthorHaft DH
Entry DateAug 29 2003 10:18AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis bacterial enzyme, ribonuclease PH, performs the final 3'-trimming and modification of tRNA precursors. This model is restricted absolutely to bacteria. Related families outside the model include proteins described as probable exosome complex exonucleases (rRNA processing) and polyribonucleotide nucleotidyltransferases (mRNA degradation). The most divergent member within the family is RNase PH from Deinococcus radiodurans.
ReferencesDR PROSITE; PS01277; Ribonuclease PH signature. DR INTERPRO; IPR002381 DR HAMAP; MF_00564; 282 of 287