HMM Summary Page: TIGR01955

Functiontranscription elongation factor/antiterminator RfaH
Gene SymbolrfaH
Trusted Cutoff144.50
Domain Trusted Cutoff144.50
Noise Cutoff93.25
Domain Noise Cutoff93.25
Isology Typeequivalog
HMM Length159
Mainrole CategoryTranscription
Subrole CategoryTranscription factors
Gene Ontology TermGO:0045449: regulation of transcription biological_process
AuthorSelengut J, Haft DH
Entry DateJul 30 2003 2:53PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the transcription elongation factor/antiterminator, RfaH [1]. This protein is most closely related to the transcriptional termination/antitermination protein NusG (TIGR00922) and contains the KOW motif (PF00467) [2]. This protein appears to be limited to the gamma proteobacteria. In E. coli, this gene appears to control the expression of haemolysin, sex factor and lipopolysaccharide genes.
ReferencesRN [1] RM PMID:20132437 RT Functional regions of the N-terminal domain of the antiterminator RfaH. RA Belogurov GA, Sevostyanova A, Svetlov V, Artsimovitch I RL Mol Microbiol. 2010 Apr;76(2):286-301. RN [2] RM PMID: 1584020 RT Escherichia coli HlyT protein, a transcriptional activator of haemolysin synthesis and secretion, is encoded by the rfaH (sfrB) locus required for expression of sex factor and lipopolysaccharide genes. RA Bailey MJ, Koronakis V, Schmoll T, Hughes C. RL Mol Microbiol. 1992 Apr;6(8):1003-12. RN [3] RM PMID: 8987397 RT KOW: a novel motif linking a bacterial transcription factor with ribosomal proteins. RA Kyrpides NC, Woese CR, Ouzounis CA. RL Trends Biochem Sci. 1996 Nov;21(11):425-6.