| Accession | TIGR01953 |
| Name | NusA |
| Function | transcription termination factor NusA |
| Gene Symbol | nusA |
| Trusted Cutoff | 253.40 |
| Domain Trusted Cutoff | 253.40 |
| Noise Cutoff | 169.10 |
| Domain Noise Cutoff | 169.10 |
| Isology Type | equivalog_domain |
| HMM Length | 340 |
| Mainrole Category | Transcription |
| Subrole Category | Transcription factors |
| Gene Ontology Term | GO:0003715: transcription termination factor activity molecular_function |
| | GO:0006353: transcription termination, DNA-dependent biological_process |
| Author | Haft DH |
| Entry Date | Jul 28 2003 10:13AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes NusA, or N utilization substance protein A, a bacterial transcription termination factor. It binds to RNA polymerase alpha subunit and promotes termination at certain RNA hairpin structures. It is named for the interaction in E. coli of phage lambda antitermination protein N with the N-utilization substance, consisting of NusA, NusB, NusE (ribosomal protein S10), and nusG. This model represents a region of NusA shared in all bacterial forms, and including an S1 (PF00575) and a KH (PF00013) RNA binding domains. Proteobacterial forms have an additional C-terminal region, not included in this model, with two repeats of 50-residue domain rich in acidic amino acids. |
| References | RN [1]
RM 11040219
RT The alpha subunit of E. coli RNA polymerase activates RNA binding by NusA.
RA Mah TF, Kuznedelov K, Mushegian A, Severinov K, Greenblatt J.
RL Genes Dev. 2000 Oct 15;14(20):2664-75 |
| Genome Property | GenProp0132: transcription termination - antitermination Nus factors (HMM) |
| | GenProp0799: bacterial core gene set, exactly 1 per genome (HMM) |
