HMM Summary Page: TIGR01950

Functionredox-sensitive transcriptional activator SoxR
Gene SymbolsoxR
Trusted Cutoff116.90
Domain Trusted Cutoff116.90
Noise Cutoff85.30
Domain Noise Cutoff85.30
Isology Typeequivalog
HMM Length142
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0003700: sequence-specific DNA binding transcription factor activity molecular_function
GO:0006355: regulation of transcription, DNA-dependent biological_process
AuthorHaft DH
Entry DateJul 25 2003 2:19PM
Last ModifiedFeb 14 2011 3:27PM
CommentSoxR is a MerR-family homodimeric transcription factor with a 2Fe-2S cluster in each monomer. The motif CIGCGCxxxxxC is conserved. Oxidation of the iron-sulfur cluster activates SoxR. The physiological role in E. coli is response to oxidative stress. It is activated by superoxide, singlet oxygen, nitric oxide (NO), and hydrogen peroxide. In E. coli, SoxR increases expression of transcription factor SoxS; different downstream targets may exist in other species.