| Accession | TIGR01934 |
| Name | MenG_MenH_UbiE |
| Function | ubiquinone/menaquinone biosynthesis methyltransferase |
| Trusted Cutoff | 158.35 |
| Domain Trusted Cutoff | 158.35 |
| Noise Cutoff | 112.50 |
| Domain Noise Cutoff | 112.50 |
| Isology Type | subfamily |
| EC Number | 2.1.1.- |
| HMM Length | 223 |
| Gene Ontology Term | GO:0008168: methyltransferase activity molecular_function |
| | GO:0008299: isoprenoid biosynthetic process biological_process |
| Author | Selengut J |
| Entry Date | Jul 22 2003 4:23PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli [1] are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (PF01209) which also contains ubiquinone methyltransferases and other methyltransferases.
Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides [2].
Note that a number of non-orthologous genes which are members of PF03737 have been erroneously annotated as MenG methyltransferases. |
| References | RN [1]
RM PMID: 9045837
RT A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene.
RA Lee PT, Hsu AY, Ha HT, Clarke CF.
RL J Bacteriol. 1997 Mar;179(5):1748-54.
RN [2]
RM PMID: 8340421
RT Isolation and functional expression in Escherichia coli of a gene encoding phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides.
RA Arondel V, Benning C, Somerville CR.
RL J Biol Chem. 1993 Jul 25;268(21):16002-8.
DR HAMAP; MF_01813; 269 of 275 |
| Genome Property | GenProp0058: menaquinone biosynthesis via SEPHCHC (HMM) |
| | GenProp0136: ubiquinone biosynthesis from chorismate, aerobic (HMM) |
