HMM Summary Page: TIGR01934

Functionubiquinone/menaquinone biosynthesis methyltransferase
Trusted Cutoff158.35
Domain Trusted Cutoff158.35
Noise Cutoff112.50
Domain Noise Cutoff112.50
Isology Typesubfamily
EC Number2.1.1.-
HMM Length223
Gene Ontology TermGO:0008168: methyltransferase activity molecular_function
GO:0008299: isoprenoid biosynthetic process biological_process
AuthorSelengut J
Entry DateJul 22 2003 4:23PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli [1] are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (PF01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC from Rhodobacter sphaeroides [2]. Note that a number of non-orthologous genes which are members of PF03737 have been erroneously annotated as MenG methyltransferases.
ReferencesRN [1] RM PMID: 9045837 RT A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene. RA Lee PT, Hsu AY, Ha HT, Clarke CF. RL J Bacteriol. 1997 Mar;179(5):1748-54. RN [2] RM PMID: 8340421 RT Isolation and functional expression in Escherichia coli of a gene encoding phosphatidylethanolamine methyltransferase (EC from Rhodobacter sphaeroides. RA Arondel V, Benning C, Somerville CR. RL J Biol Chem. 1993 Jul 25;268(21):16002-8. DR HAMAP; MF_01813; 269 of 275
Genome PropertyGenProp0058: menaquinone biosynthesis via SEPHCHC (HMM)
GenProp0136: ubiquinone biosynthesis from chorismate, aerobic (HMM)