HMM Summary Page: TIGR01933

FunctionHflK protein
Gene SymbolhflK
Trusted Cutoff159.40
Domain Trusted Cutoff159.40
Noise Cutoff133.10
Domain Noise Cutoff133.10
Isology Typeequivalog
HMM Length261
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0030288: outer membrane-bounded periplasmic space cellular_component
GO:0045861: negative regulation of proteolysis biological_process
AuthorHaft DH
Entry DateJul 22 2003 3:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentHflK and HflC are paralogs encoded by tandem genes in Proteobacteria, spirochetes, and some other bacterial lineages. The HflKC complex is anchored in the membrane and exposed to the periplasm. The complex is not active as a protease, but rather binds to and appears to modulate the ATP-dependent protease FtsH. The overall function of HflKC is not fully described.//Regulation of FtsH by HflKC appears to be negative (PMID:8947034,PMID:96367) [SS 8/27/03]
ReferencesRN [1] RM 9792691 RT Translocation, folding, and stability of the HflKC complex with signal anchor topogenic sequences. RA Kihara A, Ito K. RL J Biol Chem. 1998 Nov 6;273(45):29770-5. RN [2] RM 10512625 RT Self-processing of FtsH and its implication for the cleavage specificity of this protease. RA Akiyama Y. RL Biochemistry. 1999 Sep 7;38(36):11693-9.
Genome PropertyGenProp0684: FtsH/HflKC protease complex (HMM)