| Accession | TIGR01932 |
| Name | hflC |
| Function | HflC protein |
| Gene Symbol | hflC |
| Trusted Cutoff | 134.40 |
| Domain Trusted Cutoff | 134.40 |
| Noise Cutoff | 81.00 |
| Domain Noise Cutoff | 81.00 |
| Isology Type | equivalog |
| HMM Length | 318 |
| Mainrole Category | Protein fate |
| Subrole Category | Degradation of proteins, peptides, and glycopeptides |
| Gene Ontology Term | GO:0003674: molecular_function molecular_function |
| | GO:0030288: outer membrane-bounded periplasmic space cellular_component |
| | GO:0045861: negative regulation of proteolysis biological_process |
| Author | Haft DH |
| Entry Date | Jul 22 2003 3:01PM |
| Last Modified | Mar 2 2012 11:56AM |
| Comment | HflK and HflC are paralogs encoded by tandem genes in Proteobacteria, spirochetes, and some other bacterial lineages. The HflKC complex is anchored in the membrane and exposed to the periplasm. The complex is not active as a protease, but rather binds to and appears to modulate the ATP-dependent protease FtsH. The overall function of HflKC is not fully described. |
| References | RN [1]
RM 9792691
RT Translocation, folding, and stability of the HflKC complex with signal anchor topogenic sequences.
RA Kihara A, Ito K.
RL J Biol Chem. 1998 Nov 6;273(45):29770-5.
RN [2]
RM 10512625
RT Self-processing of FtsH and its implication for the cleavage specificity of this protease.
RA Akiyama Y.
RL Biochemistry. 1999 Sep 7;38(36):11693-9. |
| Genome Property | GenProp0684: FtsH/HflKC protease complex (HMM) |
