HMM Summary Page: TIGR01930

Functionacetyl-CoA C-acyltransferase
Trusted Cutoff240.55
Domain Trusted Cutoff240.55
Noise Cutoff180.65
Domain Noise Cutoff180.65
Isology Typesubfamily
EC Number2.3.1.16
HMM Length385
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryOther
Gene Ontology TermGO:0003985: acetyl-CoA C-acetyltransferase activity molecular_function
GO:0006631: fatty acid metabolic process biological_process
AuthorSelengut J
Entry DateJul 17 2003 10:30AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a large family of enzymes which catalyze the thiolysis of a linear fatty acid CoA (or acetoacetyl-CoA) using a second CoA molecule to produce acetyl-CoA and a CoA-ester product two carbons shorter (or, alternatively, the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA and CoA). This enzyme is also known as "thiolase", "3-ketoacyl-CoA thiolase", "beta-ketothiolase" and "Fatty oxidation complex beta subunit". When catalyzing the degradative reaction on fatty acids the corresponding EC number is The condensation reaction corresponds to Note that the enzymes which catalyze the condensation are generally not involved in fatty acid biosynthesis, which is carried out by a decarboxylating condensation of acetyl and malonyl esters of acyl carrier proteins. Rather, this activity may produce acetoacetyl-CoA for pathways such as IPP biosynthesis in the absence of sufficient fatty acid oxidation.
ReferencesDR HAMAP; MF_01620; 84 of 84
Genome PropertyGenProp0283: beta-ketoadipate degradation to succinyl-CoA and acetyl-CoA (HMM-CLUST)