HMM Summary Page: TIGR01928

Functiono-succinylbenzoate synthase
Gene SymbolmenC
Trusted Cutoff200.65
Domain Trusted Cutoff200.65
Noise Cutoff140.35
Domain Noise Cutoff140.35
Isology Typeequivalog
EC Number4.2.1.113
HMM Length325
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMenaquinone and ubiquinone
Gene Ontology TermGO:0009234: menaquinone biosynthetic process biological_process
GO:0016836: hydro-lyase activity molecular_function
AuthorSunshine J
Entry DateJul 16 2003 10:07AM
Last ModifiedFeb 16 2011 9:41AM
CommentThis model describes the enzyme o-succinylbenzoic acid synthetase (menC) that is involved in one of the steps of the menaquinone biosynthesis pathway. It takes SHCHC and makes it into 2-succinylbenzoate. Included in this model are low GC gram positive bacteria and archaea. Also included in the seed and in the model are enzymes with the com-name of N-acylamino acid racemase (or the more general term, racemase / racemase family), which refers to the enzyme's industrial application as racemases, and not to its biological function as o-succinylbenzoic acid synthetase.
ReferencesRN [1] RM PMID: 10194342 RT Unexpected divergence of enzyme function and sequence: "N-acylamino acid racemase" is o-succinylbenzoate synthase. RA Palmer DR, Garrett JB, Sharma V, Meganathan R, Babbitt PC, Gerlt JA.
Genome PropertyGenProp0058: menaquinone biosynthesis via SEPHCHC (HMM)