HMM Summary Page: TIGR01925

Functionanti-sigma F factor
Gene SymbolspoIIAB
Trusted Cutoff91.75
Domain Trusted Cutoff91.75
Noise Cutoff78.90
Domain Noise Cutoff78.90
Isology Typeequivalog
EC Number2.7.11.1
HMM Length137
Mainrole CategoryRegulatory functions
Subrole CategoryProtein interactions
Gene Ontology TermGO:0004672: protein kinase activity molecular_function
GO:0030436: asexual sporulation biological_process
AuthorNelson WE
Entry DateJul 15 2003 9:40AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes the SpoIIAB anti-sigma F factor. Sigma F regulates spore development in B subtilis. SpoIIAB binds to sigma F, preventing formation of the transcription complex at the promoter.[1] SpoIIAA (anti-anti-sigma F factor) binds to SpoIIAB to inhibit association with sigma F, however SpoIIAB can phosphorylate SpoIIAA, causing disassociation of the SpoIIAA/B complex.[2] The SpoIIE phosphatase dephosphorylates SpoIIAA.
ReferencesRN [1] RM 8460142 RT SpoIIAB is an anti-sigma factor that binds to and inhibits transcription by regulatory protein sigma F from Bacillus subtilis. RA Duncan L, Losick R. RL Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2325-9. RN [2] RM 8358793 RT Sigma F, the first compartment-specific transcription factor of B. subtilis, is regulated by an anti-sigma factor that is also a protein kinase. RA Min KT, Hilditch CM, Diederich B, Errington J, Yudkin MD. RL Cell. 1993 Aug 27;74(4):735-42. DR HAMAP; MF_00637; 29 of 29
Genome PropertyGenProp0610: endospore formation marker gene set (HMM)