HMM Summary Page: TIGR01924

Functionanti-sigma B factor
Gene SymbolrsbW
Trusted Cutoff155.05
Domain Trusted Cutoff155.05
Noise Cutoff100.10
Domain Noise Cutoff100.10
Isology Typeequivalog
EC Number2.7.11.1
HMM Length159
AuthorNelson WE, Selengut J
Entry DateJul 11 2003 5:31PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes the anti-sigma B factor also known as serine-protein kinase RsbW. Sigma B controls the general stress regulon in B subtilis and is activated by cell stresses such as stationary phase and heat shock. RsbW binds to sigma B and prevents formation of the transcription complex at the promoter.[1] RsbV (anti-anti-sigma factor) binds to RsbW to inhibit association with sigma B, however RsbW can phosphorylate RsbV, causing disassociation of the RsbV/RsbW complex.[2] Low ATP level or environmental stress causes the dephosphorylation of RsbV.[3]
ReferencesRN [1] RM PMID: 8460143 RT Bacillus subtilis sigma B is regulated by a binding protein (RsbW) that blocks its association with core RNA polymerase. RA Benson AK, Haldenwang WG. RL Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2330-4. RN [2] RM PMID: 8144446 RT Interactions between a Bacillus subtilis anti-sigma factor (RsbW) and its antagonist (RsbV). RA Dufour A, Haldenwang WG. RL J Bacteriol. 1994 Apr;176(7):1813-20. RN [3] RM PMID: 8808936 RT Reactivation of the Bacillus subtilis anti-sigma B antagonist, RsbV, by stress- or starvation-induced phosphatase activities. RA Voelker U, Voelker A, Haldenwang WG. RL J Bacteriol. 1996 Sep;178(18):5456-63. DR HAMAP; MF_00638; 35 of 35