| Accession | TIGR01919 |
| Name | hisA-trpF |
| Function | bifunctional HisA/TrpF protein |
| Trusted Cutoff | 306.45 |
| Domain Trusted Cutoff | 306.45 |
| Noise Cutoff | 235.40 |
| Domain Noise Cutoff | 235.40 |
| Isology Type | equivalog |
| EC Number | 5.3.1.16 5.3.1.24 |
| HMM Length | 243 |
| Author | Selengut J |
| Entry Date | Jun 27 2003 10:13AM |
| Last Modified | Dec 21 2011 12:24PM |
| Comment | This model represents a bifunctional protein posessing both hisA (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase) and trpF (N-(5'phosphoribosyl)anthranilate isomerase) activities [1]. Thus, it is involved in both the histidine and tryptophan biosynthetic pathways. Enzymes with this property have been described only in the Actinobacteria (High-GC gram-positive). The enzyme is closely related to the monofunctional HisA proteins (TIGR00007) and in Actinobacteria, the classical monofunctional TrpF is generally absent. |
| References | RN [1]
RM PMID: 12634849
RT Occurrence of a putative ancient-like isomerase involved in histidine and tryptophan biosynthesis.
RA Baroma-Gomez F., Hodgson, DA
RL EMBO Rep. 2003 Mar; 4(3): 296-300
DR HAMAP; MF_01014; 32 of 447 |
| Genome Property | GenProp0037: tryptophan biosynthesis from ribose-5-phosphate (HMM) |
| | GenProp0109: histidine biosynthesis from ribose-5-phosphate (HMM) |
