HMM Summary Page: TIGR01919

Functionbifunctional HisA/TrpF protein
Trusted Cutoff306.45
Domain Trusted Cutoff306.45
Noise Cutoff235.40
Domain Noise Cutoff235.40
Isology Typeequivalog
EC Number5.3.1.16
HMM Length243
AuthorSelengut J
Entry DateJun 27 2003 10:13AM
Last ModifiedDec 21 2011 12:24PM
CommentThis model represents a bifunctional protein posessing both hisA (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase) and trpF (N-(5'phosphoribosyl)anthranilate isomerase) activities [1]. Thus, it is involved in both the histidine and tryptophan biosynthetic pathways. Enzymes with this property have been described only in the Actinobacteria (High-GC gram-positive). The enzyme is closely related to the monofunctional HisA proteins (TIGR00007) and in Actinobacteria, the classical monofunctional TrpF is generally absent.
ReferencesRN [1] RM PMID: 12634849 RT Occurrence of a putative ancient-like isomerase involved in histidine and tryptophan biosynthesis. RA Baroma-Gomez F., Hodgson, DA RL EMBO Rep. 2003 Mar; 4(3): 296-300 DR HAMAP; MF_01014; 32 of 447
Genome PropertyGenProp0037: tryptophan biosynthesis from ribose-5-phosphate (HMM)
GenProp0109: histidine biosynthesis from ribose-5-phosphate (HMM)