| Accession | TIGR01916 |
| Name | F420_cofE |
| Function | coenzyme F420-0:L-glutamate ligase |
| Gene Symbol | cofE |
| Trusted Cutoff | 180.65 |
| Domain Trusted Cutoff | 180.65 |
| Noise Cutoff | 130.70 |
| Domain Noise Cutoff | 130.70 |
| Isology Type | equivalog |
| EC Number | 6.3.2.31 |
| HMM Length | 244 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Other |
| Gene Ontology Term | GO:0009108: coenzyme biosynthetic process biological_process |
| | GO:0043773: coenzyme F420-0 gamma-glutamyl ligase activity molecular_function |
| Author | Haft DH |
| Entry Date | Jun 18 2003 2:15PM |
| Last Modified | Feb 20 2011 5:25PM |
| Comment | This model represents an enzyme of coenzyme F(420) biosynthesis, as catalyzed by MJ0768 of Methanococcus jannaschii and by the N-terminal half of FbiB of Mycobacterium bovis strain BCG. Note that only two glutamates are ligated in M. jannaschii, but five to six in the Mycobacterium lineage. In M. jannaschii, CofE catalyzes the GTP-dependent addition of two L-glutamates. |
| References | RN [1]
RM PMID:11717263
RT Use of transposon Tn5367 mutagenesis and a nitroimidazopyran-based selection system to demonstrate a requirement for fbiA and fbiB in coenzyme F(420) biosynthesis by Mycobacterium bovis BCG.
RA Choi KP, Bair TB, Bae YM, Daniels L
RL J Bacteriol. 2001 Dec;183(24):7058-66.
RN [2]
RM PMID:12911320
RT CofE catalyzes the addition of two glutamates to F420-0 in F420 coenzyme biosynthesis in Methanococcus jannaschii.
RA Li H, Graupner M, Xu H, White RH
RL Biochemistry. 2003 Aug 19;42(32):9771-8.
DR HAMAP; MF_01259; 11 of 11 |
| Genome Property | GenProp0791: coenzyme F420 biosynthesis (HMM) |
