HMM Summary Page: TIGR01916

Functioncoenzyme F420-0:L-glutamate ligase
Gene SymbolcofE
Trusted Cutoff180.65
Domain Trusted Cutoff180.65
Noise Cutoff130.70
Domain Noise Cutoff130.70
Isology Typeequivalog
EC Number6.3.2.31
HMM Length244
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0009108: coenzyme biosynthetic process biological_process
GO:0043773: coenzyme F420-0 gamma-glutamyl ligase activity molecular_function
AuthorHaft DH
Entry DateJun 18 2003 2:15PM
Last ModifiedFeb 20 2011 5:25PM
CommentThis model represents an enzyme of coenzyme F(420) biosynthesis, as catalyzed by MJ0768 of Methanococcus jannaschii and by the N-terminal half of FbiB of Mycobacterium bovis strain BCG. Note that only two glutamates are ligated in M. jannaschii, but five to six in the Mycobacterium lineage. In M. jannaschii, CofE catalyzes the GTP-dependent addition of two L-glutamates.
ReferencesRN [1] RM PMID:11717263 RT Use of transposon Tn5367 mutagenesis and a nitroimidazopyran-based selection system to demonstrate a requirement for fbiA and fbiB in coenzyme F(420) biosynthesis by Mycobacterium bovis BCG. RA Choi KP, Bair TB, Bae YM, Daniels L RL J Bacteriol. 2001 Dec;183(24):7058-66. RN [2] RM PMID:12911320 RT CofE catalyzes the addition of two glutamates to F420-0 in F420 coenzyme biosynthesis in Methanococcus jannaschii. RA Li H, Graupner M, Xu H, White RH RL Biochemistry. 2003 Aug 19;42(32):9771-8. DR HAMAP; MF_01259; 11 of 11
Genome PropertyGenProp0791: coenzyme F420 biosynthesis (HMM)